In her third Paralympic Games, Popovich won six total medals, including four gold and two silver. On the way to her outstanding medal haul, Popovich set two world records and two Paralympic records. Having won 14 career gold medals, Popovich has clearly defined the standard for all swimmers.
- 2010: Five silver medals, 100m Freestyle, 400m Freestyle, 100m Breaststroke, 50m Butterfly, 200m Individual Medley; bronze medal, 50m Freestyle – IPC Swimming World Championships, Eindhoven, Netherlands
- 2008: Gold medal, 100m Freestyle S7; gold medal, 400m Freestyle S7; gold medal, 100m Breaststroke SB7; gold medal, 200m Individual Medley SM7; silver medal, 50m Butterfly S7; silver medal, 50m Freestyle S7 –Paralympic Games, Beijing, China
- 2008: First place, 50m butterfly, 100m breaststroke, 400m freestyle – U.S. Paralympic Swimming Trials, Minneapolis, Minn.
- 2007: First place, 50m butterfly, 50m freestyle, 100m butterfly, 200m individual medley; second place, 100m breaststroke, 100m freestyle – U.S. Paralympics Open Swimming Championships, College Park, Md.
- 2006: Six gold medals, 50m freestyle, 100m freestyle, 200m individual medley (WR), 400m freestyle, 4x100m freestyle relay (WR), 4x100m medley relay; two silver medals, 50m butterfly, 100m breaststroke - IPC Swimming World Championships, Durban, South Africa
- 2006: Gold medal, two bronze medals - 2006 Visa Paralympic World Cup
- 2005: Named 'Swimmer of the Year with a Disability' by Swimming World Magazine
- 2005: Five gold medals, one silver medal - U.S. Paralympics Swimming National Championships
- 2005: Named Individual Sportswoman of the Year by the Women's Sports Foundation
- 2005: ESPY Award winner - Best Female Athlete with a Disability
- 2004: Seven gold medals, 50m butterfly, 50m freestyle, 100m breaststroke, 100m freestyle, 200m individual medley, 4x100m freestyle relay, 5x100m medley relay; three world records, four Paralympic Games records - Paralympic Games, Athens, Greece
- 2004: Two world records, five American records, four Pan Am records - U.S. Paralympics Swimming Trials, Minneapolis, Minn.
- 2004: Two-time winner of U.S. Olympic Committee Athlete of the Month Award (April, September)
- 2002: Gold medal, four silver medals - IPC Swimming World Championships, Mar del Plata, Argentina
- 2000: Three gold medals, three silver medals, four world records - Paralympic Games, Sydney, Australia
- 1998: Four gold medals, bronze medal - IPC Swimming World Championships, Christchurch, New Zealand